An MMORPG mouse needs as many side buttons as you have recurring actions you actually want under your thumb. Anything beyond that is optional. List the abilities, items, or commands you press again and again and would rather not reach for on the keyboard. Then pick the smallest layout that covers that list and still feels easy to use.
That makes the right number personal. One player who wants three thumb shortcuts and another who wants ten are both choosing well, as long as each can reach and tell apart the buttons they plan to use.
Choose the Smallest Usable Count for Your Recurring Actions
Your number is the length of your thumb-shortcut list, trimmed down to the buttons you can use comfortably on a real layout. This is a practical rule of thumb, not a tested MMO standard. No single count fits every class, game, and hand.
Why aim for the smallest count that works? Extra side buttons you never assign don't make a mouse better for you. They just put more controls near your thumb that you don't need. A higher button count looks good on a spec sheet, but the useful figure is how many of those buttons you will actually bind and press during play.
To find your number, you need two inputs. The first is your shortlist of recurring actions, which the next section helps you build. The second is a hands-on check of whether the intended buttons are reachable and easy to tell apart, covered in the section after that. Your final count is whatever survives both steps.
Here's an illustrative example, not a recommendation. Say you list five actions you want on your thumb. On one mouse, you find that two of the five buttons are awkward to reach or easy to mix up. On that layout, your usable count is three. You can either move the other two actions back to the keyboard or try a different layout that fits all five.
The same logic works in reverse. If your list has only one or two items, you may not need a dedicated MMORPG mouse at all. A mouse with a couple of thumb buttons can cover that list just as well.
Which Actions Deserve a Side-Button Shortcut?
An action earns a side button when it comes up again and again in your own play and you'd honestly rather trigger it with your thumb. Everything else can stay on the keyboard. Sort your current keybinds into two groups:
- Move to the thumb: actions you press repeatedly in your normal sessions and would prefer not to stretch across the keyboard for.
- Keep on the keyboard: actions you use rarely, actions that already feel comfortable where they are, and anything you'd only bind because a button happened to be free.
Start from how you actually play, not from what the MMO label suggests. During your next few sessions, notice which keys your fingers keep returning to and which ones feel like a reach. That's your raw list. Then trim anything you added just to fill space.

Your shortlist will look different depending on your role and game. As an illustration only, a healer might list a few heals they cast constantly. A player who runs dungeons might list an interrupt and a defensive cooldown. Neither is a required set. They just show the kind of repeated, personal choices that belong on the list.
When the list is done, count it. That number is your desired side-button count before the layout check. If you play World of Warcraft dungeons, our WoW Mythic+ keybind guide compares multi-button side layouts with Shift and Ctrl modifier binds. It can help you decide whether a long list really needs that many physical buttons.
Can You Reach and Identify Those Buttons in Play?
Only count the buttons you can reach comfortably and tell apart in normal play. Treat this as a personal check on the actual layout, not a standardized test. Run it on just the buttons from your shortlist:
- Test the buttons you plan to use, not the total. Rest your hand in your natural grip and press each intended side button. Ignore the ones you won't assign.
- Judge reach and pressure. An ergonomist's mouse-selection advice says buttons should be easy to reach without forcing your fingers into an uncomfortable position. They should also be easy to press but not so sensitive that accidental clicks become an issue. Note any button that fails either part.
- Check identification separately. During ordinary play, ask yourself whether you can find the button you want without second-guessing which one sits under your thumb. Write down any pair you keep mixing up.
- Cut or switch. For each button that felt awkward, triggered too easily, or got confused with a neighbor, either move that action back to the keyboard or try a different layout. The buttons that remain are your usable count.

For one more general spacing check, the CCOHS guide on mouse selection suggests choosing buttons that neither cramp your fingers nor spread them too far apart. It's written for office mice, so use it as a comfort check for a busy thumb panel.
If you're buying online and can't hold the mouse first, review the retailer's return policy before you order. That way you can run this check at home with your real keybinds and still send it back if the layout doesn't work for your hand.
FAQs
Can modifier keys replace extra side buttons?
They can for some players. Holding a key such as Shift or Ctrl while pressing a side button gives that one button a second action. A shorter row of physical buttons can then cover more binds. The trade-off is the extra key press. If the combo feels as quick and reliable as a dedicated button, you may be fine with fewer side buttons. If it doesn't, give your most repeated actions their own buttons.
What if my mouse already has more buttons than I need?
You don't have to bind every button. Assign your shortlist to the buttons that passed your reach and identification check, and leave the rest empty. You can always add a bind later if a new action earns a spot. An unused button costs you nothing as long as you aren't pressing it by accident.
Can I change what each side button does after I buy?
On mice that support remapping through driver software, yes. That lets you adjust your binds as your class, role, or game changes, without buying a new mouse. For our own mouse, the M4 driver and manuals page covers button mapping and other setup details. For any other mouse, look up its driver or manual to see what you can reassign.
Does this approach work for games other than MMOs?
Yes. The idea of mapping only the actions you repeat to controls you can reach works in other genres too. MOBA players face a similar choice. Our Dota 2 keybind guide covers mapping emergency items to reachable controls. Our League kiting button setup focuses on a simple layout that cuts down on misclicks.